First up, the awesome Achewood. The characters are based on a pile of stuffed animals; there's a 5 yr old, an IT guy, a couple of drunks, an elder gentleman and some really hilarious references. Sample below:
Next, check out Dr. McNinja. He is a doctor who is also a ninja. Although I think he is predominately a ninja. Sample!
If you're not dead with laughter yet, move on to #3 - Don't Forget to Validate Your Parking! The best part about this comic is the dialogue. It's like a graphic novel version of Entourage, and just as funny. The narrator is a young screenwriter, and the comic centers around the friends, agents, and clients in his life. Sample, people, sample:
Last, but certainly not least, check out dinosaur comics. Again, this strip is a master of language; the same panels get reused, but the dialogue tells a million hilarious stories. Sample now: